The need for new potent antibiotics to fight both gram negative and gram positive bacteria is overwhelmingly extant in today’s society. Cystobactamides may hold the key to filling this void in medical resources, but they cannot be isolated in any amount to be used in the medical field. In order to combat this issue, the complete synthesis of cystobactamide 861-2 has been developed and optimized to make this compound in high enough yields to complete all of the necessary tests. The yield of the step that was optimized was increased from 35% to 56%. This increase in yield was made in the third step of the reaction increasing the overall yield by 20 %.<br/><br/><br/>

Synthesis of super potent antibiotic cystobactamide 861-2

253rd National Meeting (2017)

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