Polysaccharide-based multilayer thin films enable storage and sustained release of controlled doses of different drugs, which is important in local treatment of chronic wounds (e.g. chronic venous ulcers). Due to possible control of such systems’ preparation procedures, we can study them in detail as in the case of model systems. Different performance testing of such thin films (e.g. in vitro drug release, cell testing) can be used as a wound dressing on their own or be correlated to commercial wound dressings, and hence boosting the development of advanced wound care solutions. Based on the mentioned, was the aim of our study the development of a platform for the design and testing of potential novel wound dressings. These were prepared in the form of multi-layered nanofilms consisting of oppositely charged polysaccharides with the target application being the treatment of chronic venous ulcers using pharmacotherapy with pentoxifylline (PTX). Using a combination of biocompatible cationic trimethyl chitosan (TMC) and anionic alginate (ALG) polysaccharides, and the potent anti-inflammatory drug PTX, we prepared and characterized an advanced wound dressing for the treatment of chronic venous ulceration based on controlled delivery of a personalized dose of PTX. Among others, its high potential for future use, can be deduced from the in vitro cell testing on human skin cells, showing an improved cell viability after exposure to the developed system, indicating possible improved healing performance.

Multi-layered polysaccharide based nanofilms for the treatment of chronic venous ulceration

253rd National Meeting (2017)

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