Visible light sensitization is an attractive means to initiate organic reactions due to the lack of visible light absorbance by organic compounds reducing side reactions often associated with photochemical reactions conducted with high energy UV light. In particular, the use of photocatalysts such as Ru(bpy)<sub>3</sub>Cl<sub>2</sub> offer improved chemoselectivity over current approaches while enabling the reduction of stoichiometric waste byproducts and toxic or hazardous reagents. The use of continuous flow techniques may offer the most efficient route to scaling up visible light photoredox methodologies. This talk will summarize the efforts toward this goal with focus on the introduction of pharmaceutically relevant fluoroalkyl groups onto aromatic systems.

Preparative fluoroalkylation via visible light induced electron transfer

253rd National Meeting (2017)

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