Intramolecular strain can be used as a general mechanism to generate photochemically reactive Ru(II) complexes. The products of the photochemical reaction can directly damage nucleic acids in vitro and in cells. The structure activity relationships (SAR) that regulate this photochemistry, however, have not been defined. Different compounds produce different photochemical products, and the impact of the resulting compound structures on the biological effect of the adducts remains to be understood. A systematic study of the relationship of ligand and complex structure and resulting photochemistry will be presented. Alterations in the structure of the product of the photochemical reaction can result in different mechanisms of nucleic acid damage, with a concomitant, variable impacts on nucleic acid function and cell health.<br/>

Regulating photochemistry and nucleic acid targeting of Ru(II) complexes

253rd National Meeting (2017)

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