Reversed-phase flash chromatography is growing in use within medicinal chemistry labs.  One reason for this is increasing intermediate polarity which challenges the capabilities of normal-phase purification and the other is that reversed-phase chromatography is greener than normal-phase.  However, one of the popular solvents in reversed-phase is acetonitrile which is toxic and expensive.<br/><br/>In this poster we explore the use of acetone as a replacement for acetonitrile in reversed-phase flash chromatography.

Greener reversed-phase flash chromatography using acetone instead of acetonitrile

253rd National Meeting (2017)

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