Upconverting nanoparticles (UCNPs) decorated with gold is used as the sensor for the detection of glucose. The measurement is based on the response of UCNPs to temperature change as glucose concentration varies.  A two laser experiment is performed where 980 CW light is used to excite the UCNPs while 532 nm pulsed light heats the gold decorated UCNPs. The presence of glucose in the solution shifts the plasmon resonance causing a change in the amount of heating by the pulsed laser.  The modulated change in temperature is demodulated with a lock-in amplifier to give quantitative information on glucose concentration.  Gold nanoparticles on the UCNPs are functionalized with glucose oxidase for selective trapping of glucose in the biological medium.  The selectivity of the biosensor is tested in the presence of physiological ionic strength.

Biosensor based on Au-UCNP for dynamic detection of glucose

254th National Meeting (2017)

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