We synthesized block copolymers (BCPs) that contain photoactivatable Ru complexes on the polymer side chain or backbone. The Ru complexes act as photocleavable moieties, singlet oxygen sensitizers, and anticancer agents. Depending on the molecular weight and chemical structure, the BCPs assembled into micelles, vesicles, large compound micelles and other nanostructures. The BCP assemblies can be taken up by cancer cells. Red light can pass through tissue and activate the Ru-containing BCP assemblies. We demonstrated anticancer activities of the photoactivatable Ru-containing BCPs <i>in vitro</i> and <i>in vivo</i>.

Red-light-responsive Ru-containing polymers for deep-tissue phototherapy

254th National Meeting (2017)

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