A key issue in the use of nanomaterials is controlling how they interact with themselves and with the outer world. Our research program focuses on the tailoring of nanoparticles of surfaces for a variety of applications, coupling the atomic-level control provided by organic synthesis with the fundamental principles of supramolecular chemistry. Using these nanoparticles, we are developing new strategies for biological applications This talk will focus on the interfacing of nanoparticles with biosystems, and will discuss the application of self-asssembled nanoparticles as delivery vehicles. We will demonstrate the delivery of proteins and nucleic acids into the cytosol, including functional CRISPR systems. We will also show how this efficient cellular delivery translates into effective systems <i>in vivo.</i>

Nanoparticle-mediated delivery of biologics: From siRNA to CRISPR

254th National Meeting (2017)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.