Bacterial biofilms can be incorporated in useful technologies for such ends as energy production in microbial fuel cells. Research on the promotion of surface colonization by beneficial microbes is far less common than that of anti-fouling technologies to deter unwanted microbial colonization. To address the need for robust adherence of desired bacterial species, we have produced surfaces functionalized with reversible addition-fragmentation chain transfer (RAFT) glycopolymers. These polymers have mannose moieties along their length. Mannose as a saccharide that binds to our species of interest, <i>Shewanella oneidensis, </i>was found to increase bacterial binding to gold surfaces and to enrich the target cells over a strain without the protein necessary for mannose interaction. We used patterning of the polymers to produce a system of living cells organized in well-defined geometries. The use of RAFT polymers produces greater colonization promotion than non-polymeric mannose surface functionalization that has been previously reported. The thiol terminus enables facile functionalization of our substrates.

Surface functionalization with glycopolymers for selective adherence of the bacteria <i>Shewanella oneidensis</i>

255th National Meeting (2018)

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Surface functionalization with glycopolymers for selective adherence of the bacteria Shewanella oneidensis