The goal of the project was to synthesize an esterified bromo-calcein derivative through a Friedel-Crafts-like reaction, to which a “clickable” tag would be added. The highly polar clickable calcein could then be introduced into giant vesicles (GVs) to monitor the invasion of biomolecules into the GVs. In order to synthesize the calcein, a modified resorcinol also needed to be prepared. The synthesis of calceins usually requires long reaction times and high temperatures; therefore, microwave (µW) heating was used instead of conventional heating

Synthesis of an esterified calcein through a Friedel-Crafts-like reaction, by first synthesizing a modified resorcinol through a Mannich reaction, in order to make a membrane impermeable clickable fluorescent probe

255th National Meeting (2018)

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