Photothermal therapy (PTT) and photodynamic therapy (PDT) are promising tumor treatments. It is of great necessity to combine the two treatments to get more effective therapy of tumors. In this work, laponite (LAP) nanodisks were used as a platform to load indocyanine green (ICG) and then the ICG-loaded LAP nanodisks were coated with polydopamine (PDA) and modified with arginylglycylaspartic acid (RGD) peptide via a polyethylene glycol (PEG) spacer. The formed ICG/LAP-PDA-PEG-RGD particles were thoroughly characterized. We show that the photostability and photothermal stability of ICG has been significantly improved after loading of ICG within the LAP. More importantly, the photothermal conversion property of the ICG/LAP-PDA-PEG-RGD has been enhanced due to the co-existence of the PDA coating. The developed ICG/LAP-PDA-PEG-RGD platform is colloidally stable and cytocompatible in a given concentration range. Additionally, with the near-infrared absorption property of the ICG/LAP-PDA-PEG-RGD particles and the RGD-mediated targeting specificity, the ICG/LAP-PDA-PEG-RGD particles are able to target breast cancer cells overexpressing α<sub>v</sub>β<sub>3</sub> integrin and exert their killing efficacy through combination PTT and PDT. The developed ICG/LAP-PDA-PEG-RGD platform may have tremendous potential for combination PTT and PDT of tumors.

Loading of indocyanine green within polydopamine-coated laponite nanodisks for targeted cancer photothermal and photodynamic therapy

255th National Meeting (2018)

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