Parahydrogen based hyperpolarization is an exciting frontier of organic, analytical and physical chemistry. This revolutionary NMR hyperpolarization technique radically alters the “landscape” of Magnetic Resonance (MR) increasing MR signal by up to tens of million folds hence enabling molecular imaging on the proton and other (e.g. 13C, 15N and 19F) nuclei. Therefore, organic synthesis of tracers enriched with magnetically active stable isotopes is required in order to generate sufficient hyperpolarization payload (the product of the number of hyperpolarized nuclei and their NMR polarization). We report new synthetic strategies enabling 15N, 13C and 19F enrichment of carboxylic acids, imidazole & pyridine based scaffolds allowing efficient NMR hyperpolarization (approaching theoretical maximum of unity) at concentrations suitable for biomedical imaging applications.

Synthetic strategies enabling magnetic isotopes enrichment for parahydrogen based hyperpolarization

255th National Meeting (2018)

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