Since our presentation on 235<sup>th</sup> ACS National Meeting in New Orleans about TMSCl as a perspective condensing agent more than 20 papers were published by our group using the reagent. In 2009 the water scavenging properties of TMSCl was reviewed by us. A lot of heterocyclizations including Biginelly, Friedlander, Pictet–Spengler, T-effect reactions, chromone recyclizations as well as MCR reactions based of azometines were expanded with the reagent. The methodology developed was adapted to parallel synthesis and the chemical space covered by the procedures was included into REAL Database product of Enamine. More than 30 synthetic trees from REAL Database based on the TMSCl promoted reactions giving more than 20 mio of validated virtual compounds. More than 20 k compounds were synthesized in a course of the program. The lecture will showcase the critical analysis of the statistics obtained during last 10 years and more accurate feasibility, scope and limitation of the procedures in comparison with the primary scientific publications.

Trimethylchlorosilane as water scavenger: 10 years after presentation on 235<sup>th</sup> ACS National Meeting in New Orleans

255th National Meeting (2018)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

Trimethylchlorosilane as water scavenger: 10 years after presentation on 235th ACS National Meeting in New Orleans

Trimethylchlorosilane as water scavenger: 10 years after presentation on 235^th ACS National Meeting in New Orleans