Chemokine receptors are a large family of G protein-coupled receptors (GPCRs) that play a role in cell migration, activation, and maintenance.  The pharmaceutical industry has had a long standing interest in chemokine receptor antagonists as potential anti-inflammatory agents.  However, many chemokine receptor antagonists that target a single receptor have failed to be efficacious in clinical trials.  We became interested in dual antagonists of CC chemokine receptors 2 (CCR2) and 5 (CCR5), as anti-inflammatory agents.  In this disclosure, we describe trisubstituted cyclohexanes that are antagonists of CCR2 and CCR5.

Trisubstituted cyclohexanes as dual antagonists of CCR2 and CCR5

255th National Meeting (2018)

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