Azaheterocycles play important role in medicinal chemistry and drug discovery research among which benzimidazole, a fused bicyclic scaffold of benzene and imidazole, is considered as a privileged moiety. As a part of our ongoing research to develop greener methodologies targeted to pharmacologically relevant molecules, a new chemoselective greener route has been developed to synthesize substituted benzimidazoles and 1,2-disubstituted benzimidazoles concurrently in one-pot. Sonication was used as a green energy source to accomplish the synthesis of diversely substituted compounds with novel structures. Spectroscopic studies (FT-IR, NMR and HRMS) were carried out to elucidate the structures and in few cases X-ray crystallographic analysis was also performed. Some of these compounds demonstrated in vitro good to excellent anti-cervical cancer activity against SiHa cell lines.

Chemoselective concurrent synthesis of benzimidazoles and 1,2-disubstituted benzimidazoles: Greener route and in vitro anti-cervical cancer evaluation

255th National Meeting (2018)

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