Receptors for serotonin (5-hydroxytryptamine, 5-HT) have been implicated in a wide variety of physiological functions both in the CNS and in the periphery. Our research program has been focused on the control and balance of 5-HT2AR and 5-HT2CR systems. It has been shown that these two receptors are in oppositional control with 5-HT2AR antagonists and 5-HT2CR agonists exerting similar effects on behaviors such as impulse control and reactivity to cues. The existence of the homo and heterodimers of serotonin 5-HT2AR and 5-HT2CR may play a role in differentiating signaling in this GPCR system. Chemistry to access bivalent ligands for this system, as well as ligands attached to cholesterol and fluorophores will be discussed.

Development of ligands for serotonin 2A and 2C receptors

255th National Meeting (2018)

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