Despite the paramount historical importance of chelating polyhydroxamate ligands in coordination chemistry, such as the iron-binding ferrichrome siderophores, development of chelating polyhydroxamate ligands for f-element coordination chemistry has greatly lagged behind that of the d-elements.  Hydroxamates such as benzohydroxamates and natural siderophores have played key critical roles in illuminating the coordination and environmental chemistry of the actinides, respectively.  Furthermore, complex ligand topologies, primarily for the lanthanides, have employed hydroxamates (often in the form of hydroxypyridinones) for applications as potential MRI contrast agents, lanthanide luminescent agents, and radiopharmaceuticals.  We hereby report the synthesis of EDTA-inspired decadentate polyhydroxamate ligands with variable arm lengths, as well as insights into their coordination of lanthanides and the early actinides.

EDTA-inspired chelating poly-hydroxamate ligands for lanthanide and actinide coordination chemistry and applications

255th National Meeting (2018)

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