A high degree of addressability of DNA is attractive for establishing broadly applicable platform for the by-design assembly of nanoscale structures from inorganic nano-components. However, DNA addressability might not be sufficient for prescribing the architecture or behavior of the entire nanoscale system due to the competing effects and a large amount of information required for structural encoding. Our research explores novel concepts for creating targeted static and dynamic nano-architectures by bridging DNA-encoded nano-objects with structural plasticity and programmability of DNA macromolecular structures. Through developing by-design assembly platform and uncovering the phenomena that govern nano-systems with DNA-encoded interactions, we develop approaches for fabrication of well-defined three-dimensional lattices, two-dimensional membranes and finite-sized clusters from the multiple types of the nano-components. Our recent progress demonstrates strategy for organizing such nano-components as nanoparticles and proteins into ordered 3D arrays with engineered crystallographic symmetries, and clusters with prescribed architectures. The developed methods are also used to control a system dynamical behavior: structural transformations, specific triggering of desired configurations and molecular amplification. The application of the assembly platform for creation of optical and biomedical materials will be also discussed.

Programmable nanoparticle systems: Designed architectures, controlled processes and regulated functions

255th National Meeting (2018)

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