Naturally occurring dimeric chromanones have promising biological properties, such as cisplatin resistant anticancer activity. Detailed biological studies of the potential of dimeric chromanones as therapeutic agents have not yet been conducted due, in part, to their challenging synthesis. Anion-binding catalysis may be one solution enabling the enantioselective synthesis of bioactive dimeric chromanones. In these investigations, three families of anion-binding catalysts, thioureas, squaramides, and silanediols, were examined in their abilities to control the stereoselective synthesis of 2-alkyl-chromane-4-ones. The presentation will describe details of the studies, including how anion binding strength relates to catalyst activity and stereoselectivity.

Anion-binding catalysis in enantioselective chromanone construction

256th National Meeting (2018)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.