The deficiency of robust and practical methods for 18F-radiofluorination is a bottleneck for positron emission tomography (PET) tracer development. The first transition-metal-assisted 18F-deoxyfluorination of phenols will be presented. The transformation benefits from readily available phenols as starting materials, tolerance of moisture and ambient atmosphere, large substrate scope, and translatability to generate doses appropriate for PET imaging.

18F-Deoxyfluorination of phenols via Ru π-complexes

256th National Meeting (2018)

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