Oxazolidine-2,4-diones are an important structural motif found in a wide range of natural products, pharmaceuticals and biologically active compounds. In this presentation, a new oxidative cyclization reaction utilized in the synthesis of 5,5-disubstituted oxazolidine-2,4-diones (Figure 1) will be reported. Optimization of reaction conditions, exploration of substrate scope, including diastereospecific aspects of the reaction, a proposed reaction mechanism and application of the methodology to the synthesis of a medicinally relevant class of compounds will be described.

Synthesis of 5,5-disubstituted oxazolidine-2,4-diones utilizing an oxidative cyclization reaction

256th National Meeting (2018)

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