Composites of graphene oxide (GO) were developed to reduce toxicity and enhance biological applications. In order to achieve this, GO was first covalently attached to specific amino acid protected linkers, including lysine or phenylalanine or tryptophan. After confirmation of attachment spectroscopically, the composites were then further attached to phytosteorls and speicifc phytochemicals to impart biocompatibility as well as anti-inflammatory properties. The formed composites were then used for encapsulation of topoisomerase inhibitors. The formed product was employed as a drug release device in vitro. The cytotoxic effects of the constructs, as well as their capability to bind to breast cancer cells were examined. Additionally, the mechanism of induced cytotoxicity was studied. Electron microscopy was used to examine the morphologies of the assemblies and the formation of the composites was confirmed by FTIR and UV-VIS spectroscopy. Furthermore, the antimicrobial activity against E-Coli was also examined.

Bio-functionalization of graphene oxide for antimicrobial and drug delivery applications

256th National Meeting (2018)

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