Anisyl Sulfanyl Methyl IsoCyanide, ASMIC, is a multi-faceted isocyanide building block that provides a facile route to alkenes isocyanides. A one-pot deprotonation-alkylation/exchange process that rapidly yields functionalized tertiary isocyanides will be presented. Sulfinylation through the exchange process followed by beta-elimination gives the corresponding vinyl isocyanide.

ASMIC-driven synthesis of vinyl isocyanide

256th National Meeting (2018)

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