Oat is a multifunctional crop nutritionally superior to many other unfortified cereals. It is commonly consumed as whole grains and known to provide healthy nutrients to humans. Oats contain a unique type of compounds, avenanthramides (AVAs), which are a group of substituted <i>N</i>-cinnamoylanthranilic acids. AVAs have been reported to have anti-oxidative, anti-inflammatory, anti-itching, and anti-cancer activities. However, the biotransformation of AVAs is still largely unknown. We recently studied the biotransformation of the three major AVAs in mice and humans. Our results indicated that reduction of the double bond in the cinnamic acid unit and the cleavage of the amide bond are the major metabolic pathways of AVAs in mice and by human gut microbiota. Further mechanistic studies demonstrated that the AVAs are mainly metabolized by gut microbiota instead of liver and intestinal microsome and S9. In addition, we also observed inter-individual variations on the metabolism of AVAs by human gut microbiota and obtained different kinetic profiles of AVAs and its major microbial-derived metabolites in humans.

Interindividual variability in metabolism of oat avenanthramides by human gut microbiota

256th National Meeting (2018)

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