Combined loading of doxorubicin (DOX) and polyphenol resveratrol (RSV) in amphiphilic polycaprolactone polymeric micelles generated an increased loading of DOX Poly(ethylene glycol)-b-poly(ε-caprolactone) (PEG-b-PCL) and poly(ethylene glycol)-b-poly(γ-benzyl-ε-caprolactone) (PEG-b-PBCL) (Scheme 1) were used to generate polymeric micelles which were employed to co-load DOX and RES. The increased loading was attributed to the favorable interactions of DOX and RSV and to the interaction with benzyl substituents of PEG-b-PBCL diblock copolymer micelles. Combination loaded micelles \of PEG-b-PBCL diblock copolymer showed a significant improvement in DOX loading as compared to DOX only loaded PEG-b-PBCL. The encapsulation efficiency of DOX increased from 31.0% to 87.7% upon co-loading with RES. Combination loaded micelles also showed increased cytotoxicity to HeLa cells as compared to DOX only loaded micelles.

Combination loading of doxorubicin and resveratrol in polycaprolactone polymeric micelles

256th National Meeting (2018)

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