We create engineered protein ligands and receptors with altered biochemical and biophysical properties with several goals in mind. For example, these engineered proteins are being used as tools for studying the relationship between properties such as binding kinetics and affinity, and biological effects like cell signaling, proliferation, and migration. We are also developing these engineered proteins as therapeutics and diagnostic agents for applications including cancer and regenerative medicine. My presentation will highlight examples of engineered proteins from our lab with translational impact, in particular a natural cytokine ligand engineered to function as a receptor agonist or antagonist, for therapeutic applications in neural regeneration or cancer, respectively.

Engineering ligand-based receptor agonists or antagonists as next-generation protein therapeutics

256th National Meeting (2018)

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