Conjugation of a synthetic polymer to a protein can be thought of as a post translational modification. Bioconjugates have a range of interesting properties industrial biocatalysis and biomedicine. However, protein’s poor tolerance to thermal and chemical challenges can limit the performance of the biomaterials. In nature post-translational modifications modulate a proteins function and stability. This abstract will discuss the impact of polymer modification, as a post translational modification, on protein structure and function for a range of enzymatic proteins. Through the use of reversible deactivation radical polymerization, synthetic polymers of various functionalities can be synthesized including ones that have distinct ionic character (cationic vs anionic) as well as those with different hydrogen bonding capability. The impact of polymer structure on bioconjugate performance will be discussed as well as distinct assays for the bioconjugate properties.

Polymer-bioconjugation as post-translational modification for protein structure and function

256th National Meeting (2018)

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