Nitrogen-containing heterocyclic compounds are ubiquitous in nature, and are part of biologically active pharmaceuticals and agrochemicals. Among a large variety of nitrogen-containing compounds, heterocycles containing hydrazine moiety has received considerable attention due of their pharmacological properties and clinical applications. Here in, we report green and eco-friendly synthesis of novel dihydrophthalazine-1, 4-diones congeners as potential anti-microbial agents. The targeted chemical entities (4) have been developed by condensation of 3-(1,4-dioxo-3,4-dihydrophthalazin-(1H)-yl)-3-oxopropanenitrile (1) , benzaldehydes (2) and meldrum's acid (3) using L-proline as recyclable green catalyst in eco-friendly ethanol at RT for 15-30 min.

Synthesis and anti-microbial evaluation of novel dihydrophthalazine-1, 4-diones congeners via green synthetic methodology

256th National Meeting (2018)

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