Pseudouridine, the 5-ribosyl isomer of uridine (U) is the most abundant nucleic acid modification found in all domains of life and all types of RNA. Studies have shown that, urinary levels of pseudouridine are higher in Alzheimer’s disease (AD) patients and that RNA oxidation is a major component in the pathogenesis of Alzheimer’s disease (AD) and other neurodegenerative diseases. These studies point to a correlation between higher urinary levels of pseudouridine and oxidative stress in AD. The goal of this project is to synthesize a C5’-radical precursor for pseudouridine to study the effect of oxidative stress on RNA at this site. The synthesized substrate will be used to determine the products derived from the C5’-radical and their effect on RNA structure and function. Hence, this will provide key information about the role of this nucleoside in RNA related processes and disease etiology

The C’5-pseudouridinyl radical

256th National Meeting (2018)

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