The length of polyelectrolyte used to coat nanoparticles can greatly impact its behavior on a nanoparticle's surface. This in turn affects the behavior of nanoparticle-membrane interactions. Amine rich polyelectrolyte coatings have been shown to have significant intramolecular and intermolecular interactions between amine on the same and neighboring chains, respectively. The length of the polyelectrolyte coating impacts the degree of these interactions and affects coating density, particle stability, and membrane association. We synthesize AuNPs coated with 16-20 KD poly-oxanorboronenes of varying amine content to determine their membrane impact on model liposomes mimicking bacterial and mammalian membranes. Significantly different behavior is found compared to previous experiements conducted with 3KD poly-oxanorbornenes with similar amine content.

Impact of amine rich polyelectrolyte coating chain length on AuNP-Liposome interaction

256th National Meeting (2018)

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