We have developed an improved route to cis-1,4-cyclohexanediol (1) from inexpensive material 1,4-dioxaspiro[4.5]decan-8-one (2). Hundreds of grams of 1 could be obtained from a single batch in 5 steps with an overall yield of 25-30%. During the process, cis and trans-isomers of 6 were separated and converted to cis-1, 4-cyclohexanediol (1) respectively [Figure1].

Improved synthesis of cis-1, 4-cyclohexanediol

256th National Meeting (2018)

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