Electrohydrodynamic co-jetting provides access to a wide range of multicompartmental nanoparticles where individual compartments can be loaded with different drug/matrix combinations to enable sequential release profiles. Examples include both synthetic polymers such as PLGA or PLC, as well as natural polymers including albumin and transferrin. To ensure effective tumor targeting, multicompartmental nanoparticles will be decorated with targeting molecules including peptides and single chain antibodies. Biodistribution, tumor targeting and efficacy of muticompartmental nanoparticles loaded with siRNA will be evaluated in the context of glioblastoma therapies. Systemically administered nanoparticles can effectively traverse the blood brain barrier and provide significant improvement of survival in a mouse model of glioblastoma.<br/>

Multicompartmental nanoparticles for controlled release of combination therapies

256th National Meeting (2018)

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