Gold nanoparticles (Au NPs) have emerged as a robust and versatile platform technology for diagnostic and delivery purposes during recent years, due to their unique physicochemical and optical properties and excellent biocompatibility. Using ligands strategically designed against epitopes expressed on cells in pathological states, as well as various drug conjugates, Au NPs can function as targeted delivery systems in the detection and treatment of various dysfunctions and diseases, including cancer.<br/>We will present our recent results towards the design of various compatible gold nanoparticle ligands for enhanced colloidal stability, targeting, drug loading and controlled release. Special emphasis will be dedicated to formulations strategies to ensure ligand stability, high drug loading and optimum targeting and stability of the gold nanoparticles. Relevant biological data emphasizing the ability of the resulted gold nanoplatforms to function as stable and efficient delivery systems for doxorubicin will also be presented.

Ligand design, synthesis and formulation for gold nanoparticle stabilization, targeting, drug loading and controlled release: Towards new multi-ligand targeted nanoplatforms for doxorubicin delivery

256th National Meeting (2018)

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