Process-induced chemical contaminants 3-monochloro-1,2-propanediol (3-MCPD) esters, 2-monochloro-1,3-propanediol (2-MCPD) esters, and glycidyl esters are formed in edible vegetable oils during the deodorization step of the refining process.  As they are considered potentially carcinogenic and/or genotoxic, their presence in refined oils and foods may pose a potential health risk.  For this reason, research efforts over the last several years have focused on developing methodology for the extraction and quantitation of these contaminants in food oils, infant formula, and other complex food matrices in an effort to estimate levels of exposure.  In addition, proposed EU regulations for 3-MPCD and glycidol concentrations in infant formula and edible oils highlight the need for accurate analytical methodologies.  Methodology developed and validated by the U.S. Food and Drug Administration (FDA) for extracting and analyzing 3-MCPD and glycidyl esters from food oils, infant formula, and various food products will be briefly described in this presentation.  In addition, in order to further confirm the method’s performance, several comparisons were conducted with analytical methodologies developed by Health Canada, SGS Germany, and Nestle.  Finally, the results of several occurrence studies, showing a wide range of 3-MCPD and glycidyl ester concentrations across a variety of infant formulas and food products, will be presented. <br/>

Current research at the U.S. Food and Drug Administration related to the analysis of MCPD and glycidyl esters in refined oils and processed foods

256th National Meeting (2018)

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