Foldamers are synthetic oligomers that fold into stable secondary structure in solution. In the past few decades, there have been growing interests in the designs, synthesis and applications of foldamers. Interactions between foldamers and protein complexes are relatively new observations. One interesting system is the HCA dimer system linked by a foldamer dimer complex, which enhances the protein-protein interaction. Here we present computational investigation of the HCA dimer/foldamer system. The purpose of this study is to provide molecular level information on the purpose and effectiveness of the foldamer and its influence on protein-protein interactions. In future, we hope to use computational methods to aid the design of foldamers for other protein-protein interaction, such as those between Interleukin 4 and its complementary receptor Interleukin 4α.

Aromatic oligoamide foldamer for protein-protein interactions: A computational investigation

256th National Meeting (2018)

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