When the 2′-deoxyribose moiety of DNA undergoes oxidative damage, an initial hydrogen abstraction occurs, leading to the formation of a carbon centered radical that reacts with cellular oxygen to form a peroxyl radical. Ultimately strand breaks and abasic sites can be generated with a variety of oxydized lesions specific to the position of the original Hydrogen abstraction. In this study, lesions emanating from oxidation at the C-3′ and C-5′ of the sugar have been independently synthesized and their ability to form adducts with biologically relevant thiols containing biomolecules have been studied. Those adducts were then investigated as potential biomarkers for oxidative stress in biological systems

Independent synthesis and fate of DNA lesions generated from oxidative damage at the C-3′ and C-5′ position of deoxyribonucleotides

256th National Meeting (2018)

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