Bimodal imaging becomes an important growing field in medical diagnostics. Imaging and characterization of tumors can be more reliable and sustainable with a suited modality. For bimodal imaging several combinations of different physical investigation technologies are thinkable. For example PET/CT is standard in clinical practice; other combinations are under development (MRI/PET) or part of intensive investigations (OI/MRI). Here, we report dimeric peptides combined with bimodal imaging hybrid molecules suitable for OI/PET imaging. Advantage of this combination is e.g. an intraoperative image-guided surgery by fluorescent spectroscopy after a pre-imaging via PET and thus the chance of a very precise removal of malignant tissue and/or sentinel lymph nodes without radiation exposure for the surgeon by the very precise delineation of malignantly transformed tissues. Different fluorescent dyes, covering the visible to NIR window were connected to a NODAGA chelator (which binds very selectively the positron emitters 68Ga or 64Cu) via a short peptide sequence. In addition, we developed new fluorescent indocyanine dyes. For their design, we paid particular attention to their possible biodistribution. The different imaging building blocks were aligned to a PESIN-dimeric structure by a click reaction to form highly functional molecules. This molecular hybrid of dimeric peptide and bimodal imaging unit binds very effectively to the gastrin releasing peptide receptor (GRPR) which is for example overexpressed on human prostate carcinoma. The presentation includes synthesis, evaluation of the fluorescent-optical- and radiolabeling properties of the bimodal subunits as well as the combined dimeric bio-functional molecules. Additionally, in vitro binding studies and comparison of different other PESIN carrying structures will be presented.

Functional hybrid molecules for the visualization of cancer: Dimeric BBN7-14 dendroids combined with a bimodal molecular probe for positron emission tomography (PET) and optical imaging (OI) suited for tracking of GRPR-positive malignant tissue

2019 Spring National Meeting

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