The focus of this research is synthesizing and attaching hydrolysable linkers to a photoactive naphthalimide core and a selected drug. The compound consists of the naphthalimide core, a tail, linkers, and a drug. The photoactive element of the compound allows for selective activation when exposed to a particular wavelength of light. Upon activation, the core and linker dissociate from each other and the linker covalently binds to the target tissue allowing for time dependent release of the drug. Synthesizing new linkers for the compound increases the capabilities of localized drug delivery by altering the time necessary to hydrolyze the linker and release the drug into the bound tissue. Controlling the rate of release and location of the drug delivery is essential to efficient treatment of diseases such as cancer because the dosage and harmful side effects of the drug can be decreased while increasing the effectiveness of the treatment.

Synthesis of hydrolysable organic linkers and derivatives for localized drug delivery

2019 Spring National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.