Attenuating charge can be a powerful tool when optimizing a drug candidate.  The addition or removal of ionic groups can impact a wide range of properties including selectivity, solubility, hERG activity, and permeability.  More than two-thirds of all existing drugs can be considered to be weak electrolytes and most drugs are estimated to be 60-90% ionized at physiological pH.  The availability of public databases like ChEMBL and DrugBank enables us to evaluate the impact of ionization state on a range of physical properties and biological activities.  This presentation will provide an updated overview of the impact of acidic and basic compounds in medicinal chemistry.

Utility of acidic and basic compounds in medicinal chemistry

2019 Spring National Meeting

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