Medicinal plants such as sage that are rich in antioxidants can be used as alternative treatments for diseases that manifest themselves due to an accumulation of free oxygen radicals in the electron transport chain. Sage contains one such antioxidant, a polyphenolic known as rosmarinic acid. Previous research has explored antioxidant properties of rosmarinic acid, but its efficacy on breast cancer cells has not been tested. The purpose of this study is to determine if rosmarinic acid in one of three native sage species has the ability to decrease the cell density of triple negative breast cancer (TNBC) cells. Three Salvia species were tested for antioxidant activity of rosmarinic acid: Salvia lyrata, Salvia greggii, and Salvia officinalis. Methanol extractions and steam distillations were performed to isolate the essential oil from the sage. The antioxidant activity of the Salvia officinalis was then assessed using total phenolics and DPPH radical assays. Triple negative breast cancer cells were plated and treated with the essential oil of Salvia officinalis. Following treatment, crystal violet assays were performed to assess viable cell density and cytotoxicity. In this presentation, antioxidant activity of three sages will be discussed as well as the cytotoxicity of rosmarinic acid to TNBC cells.

Effects of rosmarinic acid, an antioxidant found in Salvia officinalis, on triple negative breast cancer cell viability

2019 Spring National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.