Glycan-binding proteins (GBPs) play critical roles in diverse cellular functions such as cell adhesion, signal transduction and immune response. Understanding the interactions between GBPs and glycans is fundamental to unveil the molecular details of many biological processes, and may project new opportunities for disease diagnostics, biomarker discovery and therapeutics development. While many research groups have developed their own strategies to study GBPs, there is an increasing gap between available arrays and fast-growing demands in various research areas. Here we report a tool set of glycan microarray and multiplex glycan bead array (MGBA) to study GBPs. Glycan microarray provides a powerful means for rapid biomarker discovery and study of efficacy of therapeutic biologics. Compared to the glycan microarray strategy that can detect glycan binding protein fast, MGBA platform is particularly suited for large population-based studies that require the analyses of large numbers of samples and glycans. Combining these two technologies, we can realize the fast and high throughput detections on GBPs.<br/>

Fast and high-throughput detection of glycan-binding proteins

2019 Spring National Meeting

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