Recent observations suggest that nitroxyl (HNO) has significant roles in biology and medicine. HNO has been considered as a promising therapeutic agent for the treatment of acute congestive heart failure. Developing a detailed understanding of the chemical and biological behavior of HNO, remains challenging due to its rapid dimerization in solution. These remains a need for the development of HNO donors that rapidly release HNO under neutral or physiological conditions. The slow release of HNO from common HNO donors restricts kinetic and mechanistic studies with biologically relevant molecules. Our group is developing photoactivatable HNO donors that release HNO on demand with high spatial and temporal control. Herein, a new family of HNO donors of general structure <b>1</b> is reported which exploit (2-quinolinyl)methyl phototriggers for releasing HNO. The synthesis of several HNO donors of general structure <b>1</b> is presented and preliminary photochemical studies aimed at rapid and selective HNO generation from these targets are described.

Development of photoactivatable (2-quinolinyl)methyl-based nitroxyl (HNO)-releasing compounds

2019 Spring National Meeting

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.