Nosocomial infections are a major factor causing death, increased morbidity among hospitalized patients. Among them, catheter associated urinary tract infections (CAUTIs) are one of the most common infections. Silver and antibiotics-coated catheters are commonly used to prevent CAUTIs but antibiotic resistance and their inconsistency in antibacterial properties pose major challenges. Studies to incorporate antimicrobial peptides (AMPs) into coated catheters has been on the rise due to their highly effective bacteria killing effects and reduced likelihood in supporting development of bacterial resistance towards peptides. Many strategies, including coating immobilization of AMPs, have been employed. However, the steps required to do so, such as atom transfer radical polymerization (ATRP), can be costly due to their stringent requirements. This study reports a cost effective, scalable and novel technique to coat an anhydrous polymeric coating laden with AMP onto silicone-based catheters, which also overcome problems posed by conventional hydrogel-based coatings. AMPs were released controllably and sustainably over time. A strong mechanical resistance towards coating peeling during movement of catheters inside the body was also demonstrated. Antibacterial tests showed high antimicrobial against gram-negative and gram-positive bacteria as compared to commercial silver-based catheters.<br/> <br/>

‘Antimicrobial peptide’-functionalized catheter for efficacious antimicrobial protection

2019 Spring National Meeting

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