<i>“Conformational restriction” </i>concept has already gained a considerable attention in medicinal chemistry. Scientists are looking more and more now for 3D-shaped saturated building blocks. In this context, intrinsically conformationally rigid bicyclic amines seem to be promising for drug discovery.<br/>In this work, we have rationally designed, synthesized and applied a library of novel/previously scarcely available diverse bicyclic amines in medicinal chemistry. The key synthesis step was photochemical [2+2]-cyclization. Details of the synthesis and application of the obtained compounds will be discussed.

Conformationally restricted pyrrolidines for drug discovery

2019 Spring National Meeting

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