A series of nickel phosphine catalysts, NiCl2(PTA)2, NiCl2(PCy3)2, NiCl2(PPh3)2, and NiCl2(DPPE), were synthesized and employed in two different “green” Suzuki-Miyaura coupling reactions. Our reaction system was designed and comprised of: (1) heterocyclic substrates which are important pharmaceutical building blocks, (2) a less expensive  and air-stable nickel catalyst, and (3) tert-amyl alcohol, a more benign solvent, as opposed to the typical use of hazardous and easily volatile solvents. The formation of the desired products, 5-(furan-3-yl)pyrimidine and 5-(2-methoxypyridin-3-yl)pyrimi-dine, were observed and determined pure by 1H and 13C NMR spectroscopy. Herein, we report the effect of the phosphine ligands on the catalytic activity of nickel complexes.

Investigation of a series of nickel phosphine catalysts for “green” suzuki-miyaura coupling reactions

2019 Spring National Meeting

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