Our current research is focused on antibiotic and antifungal resistance, which arise from the over-prescription of antimicrobials, the improper use of antimicrobials, and the widespread use of antimicrobials in agricultural settings. Our previous work included synthesis of chalcones as efflux pump inhibitors. Our new strategy is to synthesize hybrid molecules that contain an anti-fungal compound linked to an efflux pump inhibitor. These molecules will be released inside the cell and to inhibit efflux as well as kill the fungus.<br/>

Strategies toward combatting antimicrobial resistance through small molecule efflux pump inhibitors

2019 Spring National Meeting

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