Indole/indazole and quinolone sub-units are found in numerous biologically active compounds; many of which are known to exhibit anticancer, antibiotic, and/or antimicrobial activity. Therefore, a research project with the overriding goal of exploring the anticancer/antibiotic/antimicrobial activity of compounds that contain both the indole/indazole and quinolone sub-units was developed. Our specific sub-project focused on adding either an allyl or benzyl group at the N1 position of the quinolone sub-unit to previously synthesized indole-quinolone and indazole-quinolone analogues. We successfully synthesized 12 previously unreported analogues with the desired allyl and benzyl sub-unit connectivity and our research collaborators are conducting in vitro biological studies testing the anticancer/antibiotic/antimicrobial activity of each compound.

Synthesis of indolyl/indazolyl (N1 substituted) quinolones (C6 and C8 substituted) for study as possible anticancer/antibiotic/antimicrobial agents: N-allylated and N-benzylated analogues

2019 Spring National Meeting

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