Multicomponent coupling reactions that forge multiple carbon carbon bond formations in a single pot are important in that they provide key steps in building complex, bioactive molecules from simple starting materials with great efficiency. The Conjugate addition reaction of organometallic reagents to Michael acceptors and the subsequent reaction of enolate intermediates is one of the most reliable carbon carbon bond forming strategies. Multicomponent reactions initiated by conjugate addition reactions of N, S containing Michael acceptors with organometallic reagents catalyzed by metal salts are investigated. Excellent yields of 1,4-adducts can be isolated (&gt; 90%). The use of commercially available or easily prepared organometallic reagents will expedite the synthesis of a large library of these  N-, S-heterocycles from common starting materials.

Development of carbon-carbon bond formation reactions: Multicomponent coupling reactions in heterocycles synthesis

2019 Spring National Meeting

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