Development of new antibacterial therapeutics material is becoming increasingly urgent due to the rapid emergence of antibiotic-resistant superbugs, which are responsible for more than half million death each year in this world. Here we will discuss our current reports on the development of novel nano-biomaterial based on melittin antimicrobial peptide (AMP) attached transition metal dichalcogenide MoS2 based nanoplatform for targeted identification and synergistic inactivation 100% multidrug-resistant superbugs by combined photo thermal therapy (PTT), photo dynamic therapy (PDT) and AMP process. Our report shows that due to the presence of AMP, multifunctional AMP exhibits significantly improved antibacterial activity for superbugs via multimodal synergistic killing mechanism. Experimental results show that i 100% of carbapenem-resistant (CRE) Escherichia coli, β-lactamase (ESBL)–producing Klebsiella pneumoniae (KPN) and Methicillin-resistant Staphylococcus aureus (MRSA) can be killed using antimicrobial peptide attached MoS2 QDs, via synergistic killing mechanism. Possible mechanisms for synergistic killing of multidrug-resistant superbugs will be discussed

Antimicrobial-peptide-conjugated MoS2-based nanoplatform for multimodal synergistic inactivation of superbugs

2019 Spring National Meeting

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