Extensive kinetic data  were collected and analyzed via SPR  throughout the hit to lead campaign for the identification of allosteric inhibitor of the PRC2 complex though EED binding. Our investigations had demonstrated the intrinsic complexity in using the kinectic data for prospect design for hit/lead optimization. Correlations with biochemical data and structural information will be presented as well as our perspectives on where we are at on harnessing the power of  kinetic profiling in drug discovery.

Kinetic profiling in drug discovery: A case study with EED hit-to-lead program

2019 Spring National Meeting

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